التفاصيل البيبلوغرافية
| العنوان: |
Apolipoprotein M Protects Against Lipopolysaccharide-Induced Acute Lung Injury via Sphingosine-1-Phosphate Signaling. |
| المؤلفون: |
Zhu, Bin, Luo, Guang-hua, Feng, Yue-hua, Yu, Miao-mei, Zhang, Jun, Wei, Jiang, Yang, Chun, Xu, Ning, Zhang, Xiao-ying |
| المصدر: |
Inflammation; Mar2018, Vol. 41 Issue 2, p643-653, 11p |
| مصطلحات موضوعية: |
APOLIPOPROTEINS, LIPOPOLYSACCHARIDES, SPHINGOSINE-1-phosphate, CELLULAR signal transduction, ADULT respiratory distress syndrome, SEPSIS |
| مستخلص: |
It had been demonstrated that apolipoprotein M (apoM) is an important carrier of sphingosine-1-phosphate (S1P) in blood, and the S1P has critical roles in the pathogenesis of sepsis-induced acute lung injury (ALI). In the present study, we investigated whether apoM has beneficial effects in a mouse model after lipopolysaccharide (LPS)-induced ALI. Forty-eight mice were divided into two groups: male C57BL/6 wild-type (apoM+/+) group (n = 24) and apoM gene-deficient (apoM−/−) group (n = 24) and then randomly subdivided into four subgroups (n = 6 each) according to different intraperitoneal (i.p.) injection: control group, W146 group, LPS group, and LPS + W146 group. Serum levels of interleukin-1 beta (IL-1β) and mRNA levels of IL-1β, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), lung histology, wet/dry weight ratio, and immunohistochemistry were measured at 3 h after the baseline and compared in each group. Our results clearly demonstrated that IL-1β mRNA levels and other inflammatory biomarkers were significantly increased in the lungs of LPS-induced ALI apoM−/− mice compared to those of the apoM+/+ mice. Moreover, when apoM+/+ mice were treated with W146, a S1P receptor (S1PR1) antagonist, these inflammatory biomarkers could be significantly upregulated by LPS-induced ALI. Therefore, it suggests that apoM-S1P-S1PR1 signaling might underlie the pathogenesis of ALI and apoM could have physiological benefits to alleviate LPS-induced ALI. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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