التفاصيل البيبلوغرافية
| العنوان: |
Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies. |
| المؤلفون: |
Xiang, Qiong, Li, Xian-Hui, Fang, Xin-Xing, Jia, Jing, Ren, Jie, Dong, Yu-Chun, Ou-Yang, Cheng |
| المصدر: |
Technology & Health Care; 2018, Vol. 26 Issue 2, p271-278, 8p |
| مصطلحات موضوعية: |
NEUROPLASTICITY, LABORATORY rats, AGING, MILD cognitive impairment, SYNAPTOPHYSIN, ANIMAL experimentation, COGNITION disorders, HIPPOCAMPUS (Brain), MEMORY, MEMORY disorders, RATS |
| مستخلص: |
Background: The aging-related disease and associated neurodegenerative complications, such as cognitive impairment, has received increasing attention.Objective: The aim of this study was to show changes in cognitive behavior and molecular related the synaptic plasticity in aged-induced cognitive deficits rats.Methods: We used novel object recognition testing and morphological staining as well as western blot to detect changes in cognitive behavior and molecular related the synaptic plasticity.Results: The morphological changes of synaptic structure and number on hippocampal neurons and learning and memory deficits were shown during natural aging. Moreover, learning and memory improvement was associated with alterations of hippocampal synaptic plasticity-related proteins, such as SNAP-25, synaptophysin, snapsoin-1 and so on, which distributes to cognitive decline in natural aging.Conclusions: Our study provides more behavior and molecular evidence on relationship of cognitive deficits and aging. [ABSTRACT FROM AUTHOR] |
|
Copyright of Technology & Health Care is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
