التفاصيل البيبلوغرافية
| العنوان: |
Factors Associated With Prolonged Viral Shedding in Patients With Avian Influenza A(H7N9) Virus Infection. |
| المؤلفون: |
Yeming Wang, Qiang Guo, Zheng Yan, Daming Zhou, Wei Zhang, Shujun Zhou, Yu-Ping Li, Jing Yuan, Uyeki, Timothy M., Xinghua Shen, Wenjuan Wu, Hui Zhao, Yun-Fu Wu, Jia Shang, Zhengguang He, Yi Yang, Hongsheng Zhao, Yongqing Hong, Zehua Zhang, Min Wu |
| المصدر: |
Journal of Infectious Diseases; 6/1/2018, Vol. 217 Issue 11, p1708-1717, 10p |
| مصطلحات موضوعية: |
AVIAN influenza A virus, H7N9 Influenza, CRITICAL care medicine, ADULT respiratory distress syndrome, AVIAN influenza |
| مستخلص: |
Background: Data are limited on the impact of neuraminidase inhibitor (NAI) treatment on avian influenza A(H7N9) virus RNA shedding.Methods: In this multicenter, retrospective study, data were collected from adults hospitalized with A(H7N9) infection during 2013-2017 in China. We compared clinical features and A(H7N9) shedding among patients with different NAI doses and combination therapies and evaluated factors associated with A(H7N9) shedding, using Cox proportional hazards regression.Results: Among 478 patients, the median age was 56 years, 71% were male, and 37% died. The median time from illness onset to NAI treatment initiation was 8 days (interquartile range [IQR], 6-10 days), and the median duration of A(H7N9) RNA detection from onset was 15.5 days (IQR, 12-20 days). A(H7N9) RNA shedding was shorter in survivors than in patients who died (P < .001). Corticosteroid administration (hazard ratio [HR], 0.62 [95% confidence interval {CI}, .50-.77]) and delayed NAI treatment (HR, 0.90 [95% CI, .91-.96]) were independent risk factors for prolonged A(H7N9) shedding. There was no significant difference in A(H7N9) shedding duration between NAI combination treatment and monotherapy (P = .65) or between standard-dose and double-dose oseltamivir treatment (P = .70).Conclusions: Corticosteroid therapy and delayed NAI treatment were associated with prolonged A(H7N9) RNA shedding. NAI combination therapy and double-dose oseltamivir treatment were not associated with a reduced A(H7N9) shedding duration as compared to standard-dose oseltamivir. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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