التفاصيل البيبلوغرافية
| العنوان: |
Development and validation of Spasticity Index—Amyotrophic Lateral Sclerosis. |
| المؤلفون: |
Milinis, K., Tennant, A., Mills, R. J., Al‐Chalabi, A., Burke, G., Dick, D. J., Ealing, J., Hanemann, C. O., Harrower, T., McDermott, C. J., Majeed, T., Pinto, A., Talbot, K., Williams, T., Young, C. A., the TONiC study group |
| المصدر: |
Acta Neurologica Scandinavica; Jul2018, Vol. 138 Issue 1, p47-54, 8p |
| مصطلحات موضوعية: |
AMYOTROPHIC lateral sclerosis, SPASTICITY, QUALITY of life, RASCH models, NUMERICAL analysis |
| مستخلص: |
Objectives: Spasticity is a common and disabling feature of amyotrophic lateral sclerosis (ALS). There are currently no validated ALS‐specific measures of spasticity. The aim of this study was to develop and use a self‐report outcome measure for spasticity in ALS. Methods: Following semi‐structured interviews with 11 ALS patients, a draft scale was administered across ALS clinics in the UK. Internal validity of the scale was examined using the Rasch model. The numerical rating scale (NRS) for spasticity and Leeds Spasticity scale (LSS) were co‐administered. The final scale was used in a path model of spasticity and quality of life. Results: A total of 465 patients (mean age 64.7 years (SD 10), 59% male) with ALS participated. Spasticity was reported by 80% of subjects. A pool of 71 items representing main themes of physical symptoms, negative impact and modifying factors was subject to an iterative process of item reduction by Rasch analysis resulting in a 20‐item scale—the Spasticity Index for ALS (SI‐ALS)—which was unidimensional and free from differential item functioning. Moderate correlations were found with LSS and NRS‐spasticity. Incorporating the latent estimate of spasticity into a path model, greater spasticity reduced quality of life and motor function; higher motor function was associated with better quality of life. Conclusions: The SI‐ALS is a disease‐specific self‐report scale, which provides a robust interval‐level measure of spasticity in ALS. Spasticity has a substantial impact on quality of life in ALS. [ABSTRACT FROM AUTHOR] |
|
Copyright of Acta Neurologica Scandinavica is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
