التفاصيل البيبلوغرافية
| العنوان: |
Molecular analysis of the interaction between palladin and α-actinin |
| المؤلفون: |
Rönty, Mikko, Taivainen, Anu, Moza, Monica, Otey, Carol A., Carpén, Olli |
| المصدر: |
FEBS Letters; May2004, Vol. 566 Issue 1-3, p30-34, 5p |
| مصطلحات موضوعية: |
PROTEINS, ACTIN, GREEN fluorescent protein, CYTOSKELETON |
| مستخلص: |
Palladin is a novel component of stress fiber dense regions. Antisense and transient overexpression studies have indicated an important role for palladin in the regulation of actin cytoskeleton. Palladin colocalizes and coimmunoprecipitates with α-actinin, a dense region component, but the molecular details and functional significance of the interaction have not been studied. We show here a direct association between the two proteins and have mapped the binding site within a short sequence of palladin and in the carboxy-terminal calmodulin domain of α-actinin. Using transfection-based targeting assays, we show that palladin is involved in targeting of α-actinin to specific subcellular foci indicating a functional interplay between the two actin-associated proteins. [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
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