التفاصيل البيبلوغرافية
| العنوان: |
Circulating SCUBE1 levels in women with polycystic ovary syndrome. |
| Alternate Title: |
Polikistik over sendromlu kadınlarda SCUBE1 düzeyi. (Turkish) |
| المؤلفون: |
Erol, Onur, Ellidağ, Hamit Yaşar, Özel, Mustafa Kemal, Derbent, Aysel Uysal, Eren, Esin, Yılmaz, Necat |
| المصدر: |
Turkish Journal of Obstetrics & Gynecology; Sep2018, Vol. 15 Issue 3, p152-158, 7p |
| مصطلحات موضوعية: |
POLYCYSTIC ovary syndrome, CARDIOVASCULAR diseases, BIOMARKERS, BLOOD platelet activation, CELLULAR signal transduction, EPIDERMAL growth factor, GLUCOSE tolerance tests, RESEARCH funding, STATISTICS, DATA analysis, BODY mass index, GENETICS, DIAGNOSIS |
| Abstract (English): |
Objective: Polycystic ovary syndrome (PCOS) is thought to represent an early manifestation of metabolic syndrome, which is associated with cardiovascular disease. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal growth factor domain-containing protein 1 (SCUBE1) is a platelet activation marker that plays important roles in vascular biology and has been closely linked to cardiovascular events. In the present study, we investigated SCUBE1 levels in lean glucose-tolerant women with PCOS and assessed the possible association between SCUBE1 levels and hormonal and metabolic features of women with PCOS. Materials and Methods: The study population consisted of 90 lean [body mass index (BMI) <25 kg/m2] women who were diagnosed as having PCOS using the Rotterdam criteria and 100 age- and BMI-matched healthy controls with no clinical or biochemical feature of hyperandrogenism. Glucose tolerance was evaluated in all subjects before recruitment using the 2 h 75 g oral glucose tolerance test, and only those exhibiting normal glucose tolerance were enrolled. Hormonal and metabolic parameters, and serum SCUBE1 levels were evaluated. Results: Circulating SCUBE1 levels were significantly higher in women with PCOS than in controls (5.9±3.9 vs. 4.2±1.4 ng/mL, p=0.022). No association between SCUBE1 level and clinical or biochemical parameters was found in the control or PCOS group. Conclusion: SCUBE1 levels are elevated in women with PCOS compared with those in healthy controls; thus, this protein may be an early biomarker of cardiovascular disease later in life. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Amaç: Polikistik over sendromu (PKOS), kardiyovasküler hastalıkla ilişkili olan metabolik sendromun erken bulgusu olarak düşünülmektedir. Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-epidermal büyüme faktörü domain-containing protein 1 (SCUBE1) vasküler biyolojide önemli rol oynayan ve kardiyovasküler olaylarla yakından ilişkili olan bir trombosit aktivasyon belirtecidir. Bu çalışmada, normal kilo ve glukoz toleransı olan PKOS'li kadınlarda SCUBE1 düzeyleri ve bu düzeylerin hormonal ve metabolik özellikler arasındaki olası ilişkinin değerlendirmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya normal kiloya sahip [vücut kitle indeksi (VKİ) <25 kg/m2], Rotterdam kriterlerine göre PKOS tanısı konulan 90 hasta ile yaş ve VKİ eşleştirilmiş klinik ve biyokimyasal hiperandrojenizm bulgusu olmayan 100 kontrol hastası dahil edildi. Tüm olgulara 2 saatlik 75 gr oral glukoz tolerans testi uygulandı ve sadece normal glukoz toleransı olan olgular çalışmaya dahil edildi. Hormonal ve metabolik parametreler, serum SCUBE1 düzeyleri değerlendirildi. Bulgular: SCUBE1 seviyeleri, PKOS'li kadınlarda kontrol grubuna göre anlamlı olarak daha yüksek saptandı (5,9±3,9'a karşı 4,2±1,4 ng/mL, p=0,022). Kontrol veya PKOS grubunda SCUBE1 seviyesi ile klinik veya biyokimyasal parametreler arasında ilişki bulunmadı. Sonuç: PKOS'li kadınlarda SCUBE1 seviyeleri, sağlıklı kontrol grubundakilere göre daha yüksektir; bu nedenle, bu protein yaşamın ileri döneminde gelişebilecek kardiyovasküler hastalıkların erken biyobelirteci olabilir. [ABSTRACT FROM AUTHOR] |
|
Copyright of Turkish Journal of Obstetrics & Gynecology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder