التفاصيل البيبلوغرافية
| العنوان: |
Quantitative Analysis of Red Bone Marrow Microenvironment Cells in Patients with Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphocytic Leukemia in the Dynamics of Chemotherapy. |
| المؤلفون: |
Dolgikh, T. Yu., Kachesov, I. V., Tornuev, V. V., Vinogradova, E. V., Krinitsyna, Yu. M. |
| المصدر: |
Bulletin of Experimental Biology & Medicine; Oct2018, Vol. 165 Issue 6, p786-789, 4p |
| مصطلحات موضوعية: |
BONE marrow, TUMOR microenvironment, CANCER chemotherapy, MULTIPLE myeloma, CHRONIC myeloid leukemia |
| مستخلص: |
We performed comparative analysis of quantitative changes in the populations of bone marrow microenvironment cells in patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia in the debut, during response to chemotherapy, and during relapse/progression/loss of response. It was shown that in the active phase of hemoblastoses, the number of reticular cells and fibroblasts in trephine biopsy specimens was higher than in the phase of response to chemotherapy and than in the control group. In patients with relapse of multiple myeloma and loss of response in chronic myeloid leukemia, the percentage ratio of adipocytes in the bone marrow significantly (by 9-13-fold) increased. In addition, endotheliocytes appear in the active phase of all hemoblastoses in trephine biopsy specimens, while in the phase of response to chemotherapy and in the control group, these cells were absent. The revealed quantitative changes in bone marrow stromal cells can be taken into account during assessing the phase of hemoblastosis and effectiveness of chemotherapy. [ABSTRACT FROM AUTHOR] |
|
Copyright of Bulletin of Experimental Biology & Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder