التفاصيل البيبلوغرافية
| العنوان: |
FAS A‐670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre‐eclampsia and may contribute to HELLP syndrome: a case‐controlled study. |
| المؤلفون: |
Raguema, N, Zitouni, H, Ben Ali Gannoun, M, Benletaifa, D, Almawi, WY, Mahjoub, T, Lavoie, JL |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Dec2018, Vol. 125 Issue 13, p1758-1764, 7p, 4 Charts |
| مصطلحات موضوعية: |
GENETIC polymorphisms, PREECLAMPSIA, HELLP syndrome, POPULATION genetics |
| مستخلص: |
Objective: We evaluated the association between the Fas‐670A/G and the Fas ligand FasL IVS2nt 124 A/G polymorphisms and the risk of pre‐eclampsia and its complications. Design: A case‐controlled study. Setting: University Hospitals in most areas of Tunisia. Population: We recruited 300 pregnant women who developed pre‐eclampsia and 300 age‐matched healthy pregnant women from the same hospital. Methods: Genotyping of Fas‐670A/G and the FasL IVS2nt 124A/G gene polymorphisms were conducted using polymerase chain reaction‐restriction fragment length polymorphism among our cohort. Main outcome measures: Fisher's exact test was used to compare the statistical differences between groups for categorical variables and Student t tests were used for continuous variables. Results: The frequency of the Fas‐670G gene variant was significantly increased in women with pre‐eclampsia (42%) compared with control women (30%; P < 0.001). Also, a statistically significant difference was obtained in the distribution of the FasL IVS2nt 124G gene variant when comparing women with pre‐eclampsia (43%) with controls (30%; P < 0.001). Interestingly, we found that the carriage of Fas‐670G was associated with increased liver enzymes, suggesting an increased prevalence of the haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, a pre‐eclampsia complication. Conclusion: The Fas‐670G and FasL IVS2nt 124G polymorphisms are associated with a higher risk of pre‐eclampsia and its complications. Polymorphisms in the Fas and FasL genes are associated with increased risk of pre‐eclampsia and HELLP syndrome. Polymorphisms in the Fas and FasL genes are associated with increased risk of pre‐eclampsia and HELLP syndrome. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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