التفاصيل البيبلوغرافية
| العنوان: |
Self‐assembled poly(ethylene glycol) methyl ether‐grafted gelatin nanogels for efficient delivery of curcumin in cancer treatment. |
| المؤلفون: |
Tran, Diem‐Huong Nguyen, Pham, Linh Phuong Tran, Vo, Thanh Nguyet Nguyen, Vo, Do Minh Hoang, Nguyen, Cuu Khoa, Nguyen, Dai Hai, Nguyen, Thi Hiep, Bach, Long Giang |
| المصدر: |
Journal of Applied Polymer Science; 5/20/2019, Vol. 136 Issue 20, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
MOLECULAR self-assembly, ETHYLENE glycol, POLYMERS, METHYL ether, GELATIN, NANOGELS, CURCUMIN, CANCER treatment |
| مستخلص: |
Curcumin (CUR) is a natural active ingredient that attracted much attention for its chemotherapeutic activity against tumors without causing toxicity in healthy cells. However, it has certain limitations for being used in chemotherapy such as low aqueous solubility and hydrolytic instability in the physiological environment. In this study, self‐assembled poly(ethylene glycol) methyl ether‐grafted gelatin (Gel‐mPEG) nanogels were fabricated as delivery systems to improve the applicability of CUR in cancer treatment. CUR‐loaded Gel‐mPEG nanogels exhibited desired size range, relatively colloidal stability, and provided enhanced CUR stability in aqueous solutions. Especially, they showed significant high CUR loading capacity and better anticancer activity than free CUR as compared to previously reported CUR‐loaded nanogels according to the best of our knowledge. Moreover, the in vitro release of CUR from the nanogels was controlled and prolonged up to 96 h. These results demonstrated that Gel‐mPEG nanogels are the promising modality for the efficient delivery of CUR in cancer treatment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47544. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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