التفاصيل البيبلوغرافية
| العنوان: |
A gene-targeted polymerase-mediated strategy to identify O6-methylguanine damage. |
| المؤلفون: |
Aloisi, Claudia M. N., Sturla, Shana J., Gahlon, Hailey L. |
| المصدر: |
Chemical Communications; 4/7/2019, Vol. 55 Issue 27, p3895-3898, 4p |
| مصطلحات موضوعية: |
DNA adducts, CANCER genes, METHYLGUANINE, ETIOLOGY of cancer, DNA, GENES |
| مستخلص: |
Detecting DNA adducts in cancer genes is important for understanding cancer etiology. This study reports a strategy to identify the mutagenic DNA adduct O6-methylguanine in K-Ras. The strategy involves selective replication past a synthetic primer when placed opposite O6-methylguanine. Future work can apply this approach to other cancer-relevant genes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
