التفاصيل البيبلوغرافية
| العنوان: |
Renal artery stenosis in the antiphospholipid (Hughes) syndrome and hypertension. |
| المؤلفون: |
Sangle, S R, D'Cruz, D P, Jan, W, Karim, M Y, Khamashta, M A, Abbs, I C, Hughes, G R V |
| المصدر: |
Annals of the Rheumatic Diseases; Oct2003, p999-1002, 4p |
| مصطلحات موضوعية: |
ANTIPHOSPHOLIPID syndrome, CHI-squared test, COMPARATIVE studies, HYPERTENSION, RESEARCH methodology, MEDICAL cooperation, RADIOGRAPHY, RENAL artery, RENAL artery obstruction, RESEARCH, EVALUATION research, MAGNETIC resonance angiography, DISEASE complications |
| مستخلص: |
Background: Hypertension is common in the antiphospholipid (Hughes) syndrome (APS) and its cause is poorly understood. Anecdotal evidence suggests that renal artery stenosis (RAS) may be a relevant and treatable cause of hypertension.Objective: To investigate the prevalence of RAS in patients with APS and hypertension.Patients and Methods: Three groups of patients were evaluated: (1) 77 patients with positive antiphospholipid antibodies (aPL) (60 secondary APS, 11 primary APS, and 6 with aPL only) and uncontrolled hypertension who were receiving two or more antihypertensive drugs; (2) 91 patients (Results: Group 1: 20/77 (26%) patients had evidence of RAS (16 unilateral and 4 bilateral). Sixteen patients (80%) had smooth well defined stenoses in the proximal third of the renal artery. Three further patients had irregular arteries without distinct stenosis. Group 2: 7/91 (8%) hypertensive patients had RAS (chi(2)=10.3, p<0.001 v group 1). Group 3: 3/92 (3%) healthy donors had RAS (chi(2)=18.2, p<0.0001 v group 1).Conclusion: A significantly increased prevalence of RAS (26%) was found in patients with APS and hypertension, compared with relatively young (
|
|
Copyright of Annals of the Rheumatic Diseases is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder