التفاصيل البيبلوغرافية
| العنوان: |
The Pudovik reaction: the synthesis of bioactive α-aminophosphonates with long alkyl chains. |
| المؤلفون: |
Galkina, Irina V., Khayarov, Khasan R., Davletshin, Rustam R., Gaynullin, Aynaz Z., Gerasimov, Alexander V., Shulaeva, Marina P., Pozdeev, Oskar K., Egorova, Svetlana N., Usupova, Luiza M., Galkin, Vladimir I. |
| المصدر: |
Phosphorus, Sulfur & Silicon & the Related Elements; 2019, Vol. 194 Issue 4-6, p463-466, 4p |
| مصطلحات موضوعية: |
DIFFERENTIAL scanning calorimetry, CANDIDA albicans, GRAM-negative bacteria, THERMAL stability, THERMOGRAVIMETRY, PHOSPHORUS compounds |
| مستخلص: |
In this research we investigated the reactions of substituted naphthaldehyde with amines. The condensation of do-, tetra-, hexa-, octadecan-1-amines with 2-hydroxy-1-naphthaldehyde yielded a series of azomethines in good yields. Subsequent reaction of these compounds with didodecylphosphine oxide yielded α-aminophosphonates. The in vitro microbiological activity of the synthesized phosphorus compounds against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG/DSC). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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