التفاصيل البيبلوغرافية
| العنوان: |
Beta-carotene prevents the spermatogenic disorders induced by exogenous scrotal hyperthermia through modulations of oxidative stress, apoptosis, and androgen biosynthesis in mice. |
| المؤلفون: |
Jung-Min Yon, Jae Seung Kim, Chunmei Lin, Seul Gi Park, Lee Wha Gwon, Jong-Geol Lee, In-Jeoung Baek, Sang-Seop Nahm, Sang-Yoon Nam |
| المصدر: |
Korean Journal of Veterinary Research; 2019, Vol. 59 Issue 2, p59-67, 9p |
| مصطلحات موضوعية: |
OXIDATIVE stress, GLUTATHIONE peroxidase, FEVER, CELL death, LEYDIG cells, BIOSYNTHESIS |
| مستخلص: |
We investigated whether β-carotene (β-CA) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice were intraperitoneally treated with 10 mg/kg of β-CA or EA daily for 13 days consecutively. During this time, mice were subjected to transient scrotal heat stress in a water bath at 43°C for 20 min on day 7, and their testes and blood were obtained on day 14 for histopathologic and biochemical analyses. Heat stress induced significant testicular weight reduction, germ cell loss and degeneration, as well as abnormal localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and manganese superoxide dismutase (MnSOD) in spermatogenic and Leydig cells. Heat stress also altered the levels of oxidative stress (lipid peroxidation, SOD activity, and PHGPx, MnSOD, and HIF-1α mRNAs), apoptosis (Bax, Bcl-xL, caspase 3, NF-kB, and TGF-β1 mRNAs), and androgen biosynthesis (serological testosterone concentration and 3β-hydroxysteroid dehydrogenase mRNA) in testes. These changes were all improved significantly by β-CA treatment, but only slightly improved by EA treatment. These findings indicate that β-CA, through modulations of oxidative stress, apoptosis, and androgen biosynthesis, is a potent preventive agent against testicular injuries induced by scrotal hyperthermia. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
