التفاصيل البيبلوغرافية
| العنوان: |
Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient. |
| المؤلفون: |
Law, Nancy, Logan, Cathy, Yung, Gordon, Furr, Carrie-Lynn Langlais, Lehman, Susan M., Morales, Sandra, Rosas, Francisco, Gaidamaka, Alexander, Bilinsky, Igor, Grint, Paul, Schooley, Robert T., Aslam, Saima |
| المصدر: |
Infection; Aug2019, Vol. 47 Issue 4, p665-668, 4p, 1 Black and White Photograph, 1 Graph |
| مصطلحات موضوعية: |
ANTIBIOTICS, PSEUDOMONAS disease treatment, BIOTHERAPY, CYSTIC fibrosis, INTRAVENOUS therapy, LUNG transplantation, MULTIDRUG resistance, KIDNEY failure, RESPIRATORY insufficiency, TRANSPLANTATION of organs, tissues, etc., VIRUSES, TREATMENT effectiveness, DISEASE exacerbation, COLISTIN |
| مستخلص: |
Introduction: We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course: The patient developed multidrug resistant (MDR) Pseudomonas aeruginosa pneumonia, persistent respiratory failure, and colistin-induced renal failure. We describe the use of intravenous bacteriophage therapy (BT) along with systemic antibiotics in this patient, lack of adverse events, and clinical resolution of infection with this approach. She did not have recurrence of pseudomonal pneumonia and CF exacerbation within 100 days following the end of BT and underwent successful bilateral lung transplantation 9 months later. Conclusion: Given the concern for MDR P. aeruginosa infections in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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