التفاصيل البيبلوغرافية
| العنوان: |
Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43G298S ALS mouse model. |
| المؤلفون: |
Müller, Hans-Peter, Brenner, David, Roselli, Francesco, Wiesner, Diana, Abaei, Alireza, Gorges, Martin, Danzer, Karin M., Ludolph, Albert C., Tsao, William, Wong, Philip C., Rasche, Volker, Weishaupt, Jochen H., Kassubek, Jan |
| المصدر: |
Translational Neurodegeneration; 8/30/2019, Vol. 8 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
DIFFUSION magnetic resonance imaging, PYRAMIDAL tract, DIFFUSION tensor imaging, IMAGE analysis |
| مستخلص: |
Background: In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS). Methods: Ten mice with TDP-43G298S overexpression under control of the Thy1.2 promoter and 10 wild type (wt) underwent longitudinal DTI scans at 11.7 T, including one baseline and one follow-up scan with an interval of about 5 months. Whole brain-based spatial statistics (WBSS) of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43G298S mice compared to wt at the cohort level. Results were supplemented by tractwise fractional anisotropy statistics (TFAS) and histological evaluation of motor cortex for signs of neuronal loss. Results: Alterations at the cohort level in TDP-43G298S mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract. Neuronal loss in layer V of motor cortex was detected in TDP-43G298S at the later (but not at the earlier) timepoint compared to wt. Conclusion: DTI mapping of TDP-43G298S mice demonstrated progression in motor areas M1/M2. WBSS and TFAS are useful techniques to localize TDP-43G298S associated alterations over time in this ALS mouse model, as a biological marker. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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