التفاصيل البيبلوغرافية
| العنوان: |
REMISSION OF TREATMENT RESISTANT SCHIZOPHRENIA FOLLOWING RESECTION OF OVARIAN TERATOMA: A CASE OF ANTI-NMDAR ENCEPHALITIS. |
| المؤلفون: |
Sim Su Tein, Bin Shen Chai, Mohamad, Noor Azura Noor |
| المصدر: |
ASEAN Journal of Psychiatry; Jan-Jun2019, Vol. 20 Issue 1, p1-4, 4p |
| مصطلحات موضوعية: |
ANTI-NMDA receptor encephalitis, TERATOMA, ENCEPHALITIS, ELECTROCONVULSIVE therapy, SCHIZOPHRENIA, LANGUAGE policy |
| مستخلص: |
Objective: Ovarian teratoma has been frequently associated with Anti-N-Methyl-D-Aspartate receptor (NMDAR) encephalitis in recent years since its discovery by Dalmao in the year 2007. Most patients with anti-NMDAR encephalitis develop a multistage illness that progresses from psychosis, memory deficits, seizures, and language disintegration into a state of unresponsiveness with catatonic features often associated with abnormal movements, and autonomic and breathing instability. Milder or incomplete forms of the disorder in which patients develop predominant or apparently isolated psychiatric symptoms are uncommon. The overlap of symptomatology between anti-NMDAR encephalitis and schizophrenia often result in misdiagnosis. This case represents a forme fruste of ovarian teratoma related anti- NMDAR encephalitis which only presents with psychiatric and cognitive symptoms without obvious neurological deficits. Method: We report a case of a 37-year-old lady diagnosed with Treatment-Resistant Schizophrenia (TRS) who had a poor response to treatment despite multiple trials of antipsychotics and electroconvulsive therapy. Results: Our patient achieved remission following the excision of the ovarian teratoma and had been maintaining well with minimal psychotropic intervention. Conclusion: This case suggests that clinicians should always have a high index of suspicion for anti-NMDAR encephalitis in young women presenting with new-onset psychiatric symptoms and/or treatment-resistant psychosis. More research is needed to shed light on the exact role of NMDAR within the brain circuitry and the effects of its modulation in both Schizophrenia and anti-NMDAR encephalitis. [ABSTRACT FROM AUTHOR] |
|
Copyright of ASEAN Journal of Psychiatry is the property of ASEAN Journal of Psychiatry and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
