التفاصيل البيبلوغرافية
| العنوان: |
Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan. |
| المؤلفون: |
Harunobu Matsumoto, Mototsugu Shimokawa, Kaei Nasu, Ayumi Shikama, Takaya Shiozaki, Masayuki Futagami, Kentaro Kai, Hiroaki Nagano, Taisuke Mori, Mitsutake Yano, Norihiro Sugino, Etsuko Fujimoto, Norihito Yoshioka, Satoshi Nakagawa, Muneaki Shimada, Hideki Tokunaga, Yuki Yamada, Tomohiko Tsuruta, Kazuto Tasaki, Ryutaro Nishikawa |
| المصدر: |
Journal of Gynecologic Oncology; Nov2019, Vol. 30 Issue 6, p1-13, 13p |
| مصطلحات موضوعية: |
SMALL cell carcinoma, CARCINOMA, PROGNOSIS, RETROSPECTIVE studies, MULTIVARIATE analysis |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
Objective: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. Methods: At medical institutions participating in the Kansai Clinical Oncology Group/ Intergroup, cases diagnosed at a central pathologic review as neuroendocrine carcinoma of the endometrium between 1995 and 2014 were enrolled. We retrospectively analyzed the clinicopathologic features, treatment, prognosis and prognostic factors of this disease. Results: A total of 65 cases were registered from 18 medical institutions in Japan. Of these, 42 (64.6%) cases were diagnosed as neuroendocrine carcinoma of the endometrium based on the central pathological review and thus included in the study. Advanced International Federation of Gynecology and Obstetrics stages (stage III and IV) and pure type small cell neuroendocrine carcinoma cases had a significantly worse prognosis. Upon multivariate analysis, only histologic subtypes and surgery were significant prognostic factors. Pure type cases had a significantly worse prognosis compared to mixed type cases and complete surgery cases had a significantly better prognosis compared to cases with no or incomplete surgery. Conclusion: Our findings suggest that complete surgery improves the prognosis of neuroendocrine carcinoma of the endometrium. Even among cases with advanced disease stages, if complete surgery is expected to be achieved, clinicians should consider curative surgery to improve the prognosis of neuroendocrine carcinoma of the endometrium. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Gynecologic Oncology is the property of Korean Society of Gynecologic Oncology & Colposcopy and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder