التفاصيل البيبلوغرافية
| العنوان: |
Double Hydroboration of Quinolines via Borane Catalysis: Diastereoselective One Pot Synthesis of 3‐Hydroxytetrahydroquinolines. |
| المؤلفون: |
Kim, Eunae, Jeon, Hyun Ji, Park, Sehoon, Chang, Sukbok |
| المصدر: |
Advanced Synthesis & Catalysis; 1/23/2020, Vol. 362 Issue 2, p308-313, 6p |
| مصطلحات موضوعية: |
HYDROBORATION, QUINOLINE, BORANES, CATALYSIS, POTS, ISOQUINOLINE |
| مستخلص: |
Described herein is an organoborane‐catalysed consecutive borylative reduction of quinolines and isoquinolines to furnish tetrahydro(iso)quinolines bearing a C(sp3)−B bond β to the nitrogen atom. The installed C−B bond is oxidatively transformed to the hydroxy group in one pot. The present double hydroboration is proposed to proceed via a stepwise ionic mechanism involving a boronium ion. The stereo‐outcome was found to be dependent on the position (C2 vs C4) of the substituents in quinolines. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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