التفاصيل البيبلوغرافية
| العنوان: |
A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas. |
| المؤلفون: |
Sant' Anna, B. G., Musolino, N. R. C., Gadelha, M. R., Marques, C., Castro, M., Elias, P. C. L., Vilar, L., Lyra, R., Martins, M. R. A., Quidute, A. R. P., Abucham, J., Nazato, D., Garmes, H. M., Fontana, M. L. C., Boguszewski, C. L., Bueno, C. B., Czepielewski, M. A., Portes, E. S., Nunes-Nogueira, V. S., Ribeiro-Oliveira, A. |
| المصدر: |
Pituitary; Apr2020, Vol. 23 Issue 2, p120-128, 9p |
| مستخلص: |
Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed. [ABSTRACT FROM AUTHOR] |
|
Copyright of Pituitary is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Springer Verlag. 
Full Text Finder