التفاصيل البيبلوغرافية
| العنوان: |
Clinical outcomes after percutaneous coronary intervention in non-dialysis patients with acute coronary syndrome and advanced renal dysfunction. |
| المؤلفون: |
Uemura, Yusuke, Ishikawa, Shinji, Takemoto, Kenji, Negishi, Yosuke, Tanaka, Akihito, Takagi, Kensuke, Yoshioka, Naoyuki, Umemoto, Norio, Inoue, Yosuke, Morishima, Itsuro, Shibata, Naoki, Asano, Hiroshi, Ishii, Hideki, Watarai, Masato, Murohara, Toyoaki |
| المصدر: |
Clinical & Experimental Nephrology; Apr2020, Vol. 24 Issue 4, p339-348, 10p |
| مصطلحات موضوعية: |
PERCUTANEOUS coronary intervention, ACUTE coronary syndrome, CEREBROVASCULAR disease, ANGINA pectoris, BODY mass index, GLOMERULAR filtration rate |
| مستخلص: |
Background: Data about the clinical outcomes of ACS patients with advanced renal dysfunction (estimated glomerular filtration rate < 30 mL/min/1.73 m2) following percutaneous coronary intervention (PCI) are limited. Methods: We examined the data obtained from 194 ACS patients with non-dialysis advanced renal dysfunction who underwent PCI at five hospitals. The primary composite endpoint was the incidence of major adverse cardiac and cerebrovascular events (MACCE: all-cause death, myocardial infarction, and ischemic stroke). Results: Eighty patients (41.2%) were diagnosed with ST-elevation myocardial infarction (STEMI), and 117 patients (58.8%) with non-ST-elevation ACS (NSTE-ACS). Overall patients were followed for a median of 657.5 days. Cumulative incidence of MACCE at median follow-up was 32.3% (45.4% for STEMI and 23.4% for NSTE-ACS). Kaplan–Meier analysis demonstrated that patients in the STEMI group had significantly higher incidence of MACCE than those in the non-STEMI and unstable angina group (Log-rank p < 0.001). In-hospital MACCE rate was higher in the STEMI group than in the NSTE-ACS group, whereas post-discharge MACCE rate was comparable between the two groups. In the multivariate analysis, STEMI and Killip classification ≥ 2 were associated with in-hospital MACCE. On the other hand, body mass index and serum albumin at admission were independent predictors of post-discharge MACCE. Conclusions: Short- and long-term prognoses following PCI in non-dialysis patients with ACS and advanced renal dysfunction is still unfavorable. STEMI and Killip classification ≥ 2 were independent predictors for in-hospital MACCE, and body mass index and serum albumin were for post-discharge MACCE. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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