التفاصيل البيبلوغرافية
| العنوان: |
Age-specific reference ranges of serum anti-müllerian hormone in healthy women and its application in diagnosis of polycystic ovary syndrome: a population study. |
| المؤلفون: |
Li, HWR, He, Y‐L, Li, R, Wong, CYG, Sy, B, Lam, CW, Lam, KSL, Peng, H‐M, Mu, S, Schooling, M, Yeung, WSB, Ho, PC, Ng, EHY, He, Y-L, Lam, C W, Peng, H-M, Ho, P C |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; May2020, Vol. 127 Issue 6, p720-728, 9p, 1 Chart, 3 Graphs |
| مصطلحات موضوعية: |
ANTI-Mullerian hormone, POLYCYSTIC ovary syndrome, CHINESE people, MENSTRUATION disorders, SERUM, COMPARATIVE studies, SEX hormones, RESEARCH methodology, MEDICAL cooperation, REFERENCE values, RESEARCH, SURVEYS, WOMEN'S health, EVALUATION research, RECEIVER operating characteristic curves |
| مستخلص: |
Objective: To establish the age-specific centiles of serum anti-müllerian hormone (AMH) levels in Chinese women, and to explore the use of multiples of median (MoM) AMH levels for the diagnosis of polycystic ovary syndrome (PCOS).Design: An observational study.Setting: University-affiliated hospitals and community clinics.Population: We included 3137 healthy women aged 20-44 years recruited prospectively or who had archived serum samples from previous research projects. Another validation cohort of 751 women with PCOS as well as ovulatory controls, which was a convenient sample of women attending for infertility or menstrual disorders, was also studied.Methods: The serum samples were assayed for AMH by the automated Access AMH assay.Main Outcome Measures: Age-specific reference ranges were constructed on the primary cohort with the Lambda-Mu-Sigma method. The MoM AMH of each subject in the validation cohort was calculated.Results: Centile curves of serum AMH level against age were established. MoM AMH was significantly higher in women with PCOS than in controls (P < 0.05). The area under the ROC curve was 0.852 (95% confidence interval [CI] 0.825-0.877) (P < 0.0001) for discriminating women with PCOS from ovulatory controls by MoM AMH.Conclusions: We established a set of year-by-year age-specific reference ranges of serum AMH levels in Chinese women. The MoM AMH derived from this set of reference ranges is a promising tool to replace antral follicle count in the diagnosis of PCOS.Tweetable Abstract: A set of age-specific reference ranges of AMH levels was established in Chinese women. Multiples of median AMH may be used to diagnose PCOS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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