التفاصيل البيبلوغرافية
| العنوان: |
Association of Genetic Polymorphisms With Afatinib-induced Diarrhoea. |
| المؤلفون: |
RINTARO SOGAWA, CHIHO NAKASHIMA, TOMOMI NAKAMURA, KOJI TAKEUCHI, SAKIKO KIMURA, KAZUTOSHI KOMIYA, YUTAKA NARISAWA, SHINYA KIMURA, NAOKO SUEOKA-ARAGANE |
| المصدر: |
In Vivo; May/Jun2020, Vol. 34 Issue 3, p1415-1419, 5p |
| مصطلحات موضوعية: |
EPIDERMAL growth factor receptors, PROTEIN-tyrosine kinase inhibitors, DIARRHEA, GENETIC polymorphisms, NON-small-cell lung carcinoma, LUNG cancer treatment |
| مستخلص: |
Background/Aim: Afatinib, a 2nd generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in treatment of non-small cell lung cancer (NSCLC), causes diarrhoea in over 90% of patients. The association of genetic background with diarrhoea is poorly understood. Patients and Methods: We evaluated the roles of four single nucleotide polymorphisms (SNPs) in ATP binding cassette subfamily B member 1 (ABCB1) and ATP binding cassette subfamily G member 2 (ABCG2) genes–ABCB1 1236 C>T, 2677 G>T/A, and 3435 C>T, and ABCG2 421 C>A–on treatment-induced diarrhoea in 38 patients with NSCLC treated with afatinib. Results: Diarrhoea occurred more frequently in patients with ABCB1 2677 T(A)/T(A) (14/16, 87.5%) than in patients with non-T(A)/T(A) alleles (8/22, 36.4%) (p=0.003). ABCB1 2677 T(A)/T(A) was significantly predictive of diarrhoea (p=0.002) by multivariable regression analysis. Conclusion: Afatinib-induced diarrhoea is associated with the SNP ABCB1 2677 T(A)/T(A). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
