التفاصيل البيبلوغرافية
| العنوان: |
The synthesis of 3-phosphonoalanine, phosphonopyruvic acid and phosphonolactic acid. |
| المؤلفون: |
Sparkes, Micheal J., Rogers, Karen L., Dixon, Henry B.F. |
| المصدر: |
European Journal of Biochemistry; 12/12/90, Vol. 194 Issue 2, p373-376, 4p |
| مصطلحات موضوعية: |
ALANINE, ORGANIC synthesis, VINYL acetate, NITRITES, SODIUM compounds, CHEMICAL bonds |
| مستخلص: |
3-Phosphonoalanine has been made by the Strecker synthesis from phosphonoacetalydehyde, which is easily prepared from vinyl acetate. It gives phosphonopyruvate by transamination when treated with glyoxylate. Phosphonolactate, an analogue of phosphoglycerate, is prepared by reducing phosphonopyruvate. Diazotization of phosphonoalanine was investigated as a route for making phosphonolactate: addition of NaNO2 to the isoelectric form of Phosphonoalanine gave much scission of the C-P bond with release of phosphate: addition of HBr prevented this release and gave largely the bromo acid. The supplement reports the synthesis of arsonolactate, a similar analogue, by treating chlorolactate with alkaline arsenite. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
