التفاصيل البيبلوغرافية
| العنوان: |
炎症性肠病的自噬与表观遗传修饰. (Chinese) |
| Alternate Title: |
Autophagy and epigenetic modification in inflammatory bowel disease. (English) |
| المؤلفون: |
郭娅静, 黄艳, 施茵 |
| المصدر: |
Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu; 7/18/2020, Vol. 24 Issue 20, p3269-3274, 6p |
| مصطلحات موضوعية: |
INFLAMMATORY bowel diseases, NON-coding RNA, DNA methylation, INTESTINAL diseases, CHRONIC diseases, GENE ontology, ONLINE databases |
| Abstract (English): |
BACKGROUND: Inflammatory bowel disease is a chronic inflammatory disease associated with intestinal immune, and autophagy is a cell approach to promote immune regulation. Abnormal expression of autophagy-related genes is closely related to intestinal inflammation and immune response. However, the mehanism by which epigenetic modification regulates autophagy in inflammatory bowel disease has not been fully clarified. OBJECTIVE: To introduce the role of epigenetic modification in autophagy, and to promote a further understanding of inflammatory bowel disease. METHODS: A computer-based online research of PubMed database was performed with the key words of "inflammatory bowel disease, autophagy, autophagy-related genes, epigenetic modification, DNA methylation, histone modification, chromatin remodeling, miRNA." The search time was from January 1998 to April 2019. Finally, 61 eligible articles were included in result analysis. RESULTS AND CONCLUSION: Epigenetic modifications such as DNA methylation, histone modification, chromatin remodeling, non-coding RNA can regulate intestinal inflammation, immune and autophagy through susceptibility genes AGL and IRGM, thereby mediating the occurrence and development of inflammatory bowel disease. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
背景： 炎症性肠病是一种与肠道自身免疫相关的慢性炎症性疾病， 自噬是促进免疫调节的细胞途径，相关 基因的表达异常与肠道炎症以及免疫反应关系密切， 而表观遗传修饰对炎症性肠病自噬的调控机制尚未阐 明。 目的： 文章旨在对表观遗传修饰在炎症性肠病自噬中的调控作用作一介绍， 以期探讨炎症性肠病自噬的发 生机制。 方法： 检索PubMed 数据库， 检索时限1998 年1 月至2019 年4 月， 检索关键词为“ inflammatory bowel disease, autophagy, autophagy related genes, epigenetic modification, DNA methylation, histone modification, chromatin remodeling, miRNA", 选择61 篇符合标准的文献。结果与结论： 表观遗传{DNA 甲基化、组蛋白修饰、染色质重塑、非编码RNA)可通过修饰炎症性肠病的易 感基因ATG、IRGM 等来调控肠道炎症、免疫以及自噬， 从而介导炎症性肠病的发生和发展。 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
