التفاصيل البيبلوغرافية
| العنوان: |
Comparison of phenolics, antioxidant, and antiproliferative activities of two Hypsizygus marmoreus varieties. |
| المؤلفون: |
Xu, Qiuxiong, Wang, Hong, Li, Tong, Chen, Ling, Zheng, Bisheng, Liu, Rui Hai |
| المصدر: |
Journal of Food Science (John Wiley & Sons, Inc.); Jul2020, Vol. 85 Issue 7, p2227-2235, 9p, 4 Charts, 4 Graphs |
| مصطلحات موضوعية: |
SHIMEJI mushrooms, PHENOLS, OXIDANT status, ANTIOXIDANTS, CATECHIN, GALLIC acid, CANCER cells, CANCER cell proliferation |
| مستخلص: |
Phenolics, antioxidant activities, and antiproliferative properties of brown Hypsizygus marmoreus (brown HM) and white Hypsizygus marmoreus (white HM) were compared. The results showed that the contents of (+)‐catechin, gallic acid, and protocatechuic acid of brown HM were higher than those of white HM. Moreover, brown HM had greater cellular antioxidant activity (CAA), peroxyl radical scavenging capacity (PSC), and oxygen radical absorbance capacity (ORAC) values than white HM, which demonstrated that brown HM presented a stronger antioxidant capacity. Both of brown HM and white HM showed remarkable antiproliferative activities against HepG2 cells and brown HM was proven to be the more effective. The flow cytometry results revealed that both of brown HM and white HM could induce G1 arrest and cell apoptotics in a dose‐dependent manner. In addition, CyclinD1, CDK4, and Bcl‐2 mRNA expression levels were downregulated with the treatment of brown HM or white HM. Taken together, our study revealed that brown HM afforded better antioxidant and antiproliferative activities than white HM and laid the foundation for potential application of Hypsizygus marmoreus as source of nutraceuticals and functional food products. Practical Application: A systematic assessment of the potential differences of phenolics, antioxidant, and antiproliferative activities between different Hypsizygus marmoreus varieties was carried out in the present study. Furthermore, our findings would present possible antiproliferative mechanism of extracts of different Hypsizygus marmoreus varieties, which may provide theoretical basis for further development and utilization of Hypsizygus marmoreus. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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