التفاصيل البيبلوغرافية
| العنوان: |
Evaluation of transrectal ultrasound-based dosimetry for brachytherapy of prostate cancer: a single-center experience. |
| المؤلفون: |
Changzhao Yang, Zhengtong Lv, Lingxiao Chen, Jie Wang, Xiheng Hu, Chand, Harripersaud, Xi Sun, Guyu Tang, Congyi Tang, Huichuan Jiang, Yuan Li |
| المصدر: |
Journal of Contemporary Brachytherapy; 2020, Vol. 12 Issue 4, p327-334, 8p |
| مصطلحات موضوعية: |
HIGH dose rate brachytherapy, ENDORECTAL ultrasonography, RADIATION dosimetry, PROSTATE cancer, RADIOISOTOPE brachytherapy, PROSTATE cancer patients, EXPECTED returns |
| مستخلص: |
Purpose: To explore the possibility of intraoperative transrectal ultrasound (TRUS)-based dose verification in trans- perineal brachytherapy (BT) with iodine-125 (125I) seeds for prostate cancer. Material and methods: Fifteen patients with prostate cancer were treated using BT with 125I seeds. Post-implant TRUS and computed tomography (CT) images were imported into treatment planning system (TPS) for dosimetry. Dosimetry parameters, including minimum dose received by 90% of the volume (D90), percentage of the volume receiving 100% of prescribed dose (V100), and percentage of the volume receiving 200% of prescribed dose (V200) were calculated based on TRUS and CT images, separately. The D90 value of TRUS-based dosimetry was transformed to its expected value. Comparisons of the dosimetric parameters between post-operative verification and preoperative plans were made by paired t-test. One-way ANOVA model was used to assess the differences in preoperative plans. Agreements were evaluated between the preoperative planning and post-operative actual dose parameters using Bland-Altman analysis. Results: In total, 825 of 125I seeds were implanted successfully in 15 patients. In TRUS-based dosimetry, 674 seeds (81%) were identified clearly in TRUS-based images, and the expected value of D90 parameter showed no significant differences compared with the preoperative planning and CT post-operation results (p > 0.05). In CT-based dosimetry, 810 seeds (98%) were identified clearly in CT-based images, and there was good consistency of D90, V100, and V200 values (p > 0.05). Post-implant CT-based dosimetry indicated that 125I seed implantation had fulfilled the expected plan. Conclusions: Intraoperative TRUS can be used for dosimetric verification of BT for prostate cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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