التفاصيل البيبلوغرافية
| العنوان: |
Patterns of clinicopathological features and outcome in epithelial ovarian cancer patients: 35 years of prospectively collected data. |
| المؤلفون: |
Irodi, A, Rye, T, Herbert, K, Churchman, M, Bartos, C, Mackean, M, Nussey, F, Herrington, CS, Gourley, C, Hollis, RL, Herrington, C S, Hollis, R L |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Oct2020, Vol. 127 Issue 11, p1409-1420, 12p |
| مصطلحات موضوعية: |
OVARIAN epithelial cancer, CANCER patients, PROGNOSIS, PROGRESSION-free survival, DISEASE relapse, SURVIVAL analysis (Biometry), RESEARCH, OVARIAN tumors, RESEARCH methodology, RETROSPECTIVE studies, ACQUISITION of data, EVALUATION research, MEDICAL cooperation, TUMOR classification, COMPARATIVE studies, KAPLAN-Meier estimator, AGE factors in disease, RESEARCH funding, CYTOREDUCTIVE surgery, TUMOR grading |
| مصطلحات جغرافية: |
SCOTLAND |
| مستخلص: |
Objective: Investigate the clinical landscape of ovarian carcinoma (OC) over time.Design: Register-based prospectively collected data.Setting: South East Scotland.Sample: A total of 2805 OC patients diagnosed in 1981-2015.Methods: Survival times were visualised using the Kaplan-Meier method; median survival, 5-year survival probabilities and associated restricted mean survival time analyses were used to quantify survival differences.Main Outcome Measures: Disease-specific survival.Results: A significant increase in disease-specific survival (DSS) from 1981-1985 to 2011-2015 was observed (median 1.73 versus 4.23 years, P < 0.0001). Corresponding increase in progression-free survival (PFS) was not statistically significant (median 1.22 versus 1.58 years, P = 0.2568). An increase in the proportion of cases with low residual disease volume (RD) (<2 cm RD) following debulking was observed (54.0% versus 87.7%, P < 0.0001). The proportion of high grade serous (HGS) cases increased (P < 0.0001), whereas endometrioid and mucinous cases decreased (P = 0.0005 and P = 0.0002). Increases in stage IV HGS OC incidence (P = 0.0009) and stage IV HGS OC DSS (P = 0.0122) were observed. Increasing median age at diagnosis correlated with increasing Eastern Cooperative Oncology Group Performance Status (ECOG PS) over time (r = 0.86).Conclusions: OC DSS has improved over the last 35 years. PFS has not significantly increased, highlighting that improvement in outcome has been limited to extending post-relapse survival. Distribution of stage at diagnosis, histological subtype and RD following debulking has changed over time, reflecting evolution in tumour classification, staging and optimal debulking definitions (from low RD to minimal or zero RD). Histology, stage, RD and ECOG PS remain reliable outcome predictors. Increasing median age at diagnosis and ECOG PS indicates demographic shifts in the clinical population.Tweetable Abstract: Significant improvement in ovarian carcinoma survival has been seen over time. Most of this improvement is due to an extension of survival following disease relapse. [ABSTRACT FROM AUTHOR] |
|
Copyright of BJOG: An International Journal of Obstetrics & Gynaecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder