التفاصيل البيبلوغرافية
| العنوان: |
Amygdalohippocampal Area Neurons That Project to the Preoptic Area Mediate Infant-Directed Attack in Male Mice. |
| المؤلفون: |
Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Kazuki Ito, Kazunari Miyamichi, Masabumi Minami, Taiju Amano |
| المصدر: |
Journal of Neuroscience; 5/13/2020, Vol. 40 Issue 20, p3981-3994, 14p |
| مصطلحات موضوعية: |
PREOPTIC area, NEURONS, OXYTOCIN receptors, HORMONE receptors, PARENT-infant relationships |
| مستخلص: |
Male animals may show alternative behaviors toward infants: attack or parenting. These behaviors are triggered by pup stimuli under the influence of the internal state, including the hormonal environment and/or social experiences. Converging data suggest that the medial preoptic area (MPOA) contributes to the behavioral selection toward the pup. However, the neural mechanisms underlying how integrated stimuli affect the MPOA-dependent behavioral selection remain unclear. Here we focus on the amygdalohippocampal area (AHi) that projects to MPOA and expresses oxytocin receptor, a hormone receptor mediating social behavior toward pups. We describe the activation of MPOA-projection AHi neurons in male mice by social contact with pups. Input mapping using the TRIO method reveals that MPOA-projection AHi neurons receive prominent inputs from several regions, including the thalamus, hypothalamus, and olfactory cortex. Electrophysiological and histologic analysis demonstrates that oxytocin modulates inhibitory synaptic responses on MPOA-projection AHi neurons. In addition, AHi forms the excitatory monosynapse to MPOA, and pharmacological activation of MPOA-projection AHi neurons enhances only aggressive behavior, but not parental behavior. Interestingly, this promoted behavior was related to social experience in male mice. Collectively, our results identified a presynaptic partner of MPOA that can integrate sensory input and hormonal state, and trigger pup-directed aggression. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
