التفاصيل البيبلوغرافية
| العنوان: |
Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer. |
| المؤلفون: |
Widyaningrum, Naniek, Hussaana, Atina, Puspitasari, Nesya Ayu |
| المصدر: |
Sains Medika Journal of Medical & Health; Jan-Jun2020, Vol. 11 Issue 1, p14-19, 6p |
| مصطلحات موضوعية: |
FIG, CERVICAL cancer, GINGER, OLIVE oil, OLIVE, PAPILLOMAVIRUSES |
| Abstract (English): |
Introduction: Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity. Objective: This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells. Methods: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values. Results: The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 µg/mL, 679,593 µg/mL, 1562,356 µg/mL, 746,923µg/mL, 563,626 µg/mL and 13,707 µg/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively. Conclusion: The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells. [ABSTRACT FROM AUTHOR] |
| Abstract (Indonesian): |
Pendahuluan: Kanker serviks adalah penyakit menular ganas yang disebabkan oleh Human Papilloma Virus (HPV) di leher Rahim. Buah tin dan minyak zaitun yang mengandung flavonoid telah terbukti memiliki aktivitas antioksidan dan antikanker. Tujuan: Penelitian ini bertujuan untuk mengevaluasi aktivitas antioksidan dan sitotoksik kombinasi Ficus carica L. dan Olea europeae L. terhadap sel kanker serviks HeLa. Metode: Penelitian ini merupakan penelitian eksperimental dengan desain post-test control group. Sel HeLa dibagi menjadi 5 kelompok: ekstrak buah tin, minyak zaitun, ekstrak buah tin gabungan dan minyak zaitun (dengan perbandingan 1: 3, 1: 1, 3: 1), kontrol positif (doxorubicin). Aktivitas sitotoksik dan antioksidan masing-masing dievaluasi dengan menggunakan MTT Assay dan DPPH. Hasil sitotoksik dianalisis menggunakan probit dan aktivitas antioksidan dianalisis dengan menggunakan regresi linier untuk mendapatkan nilai IC50. Hasil: Sitotoksik IC50 dari ekstrak buah tin, minyak zaitun, kombinasi buah tin dan minyak zaitun (dengan perbandingan 1:3, 1:1, 3:1) dengan kontrol positif (doxorubicin) adalah 13063.915 µg/mL, 679.593 µg/mL, 1562.356 µg/mL, 746.923µg/mL, 563.626 µg/mL dan 13.707 µg/mL. IC50 antioksidan ekstrak tin, minyak zaitun, dan kombinasi ekstrak tin dan minyak zaitun (3:1) masing-masing adalah 105,9272 ppm, 23,1276 ppm, dan 21,0689 ppm. Kesimpulan: Kombinasi ekstrak buah tin dan minyak zaitun (3:1) terbukti memiliki aktivitas antioksidan dan sitotoksik tertinggi terhadap sel kanker serviks HeLa. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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