التفاصيل البيبلوغرافية
| العنوان: |
Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study. |
| المؤلفون: |
Prabhu, M, Cagino, K, Matthews, KC, Friedlander, RL, Glynn, SM, Kubiak, JM, Yang, YJ, Zhao, Z, Baergen, RN, DiPace, JI, Razavi, AS, Skupski, DW, Snyder, JR, Singh, HK, Kalish, RB, Oxford, CM, Riley, LE, Matthews, K C, Friedlander, R L, Glynn, S M |
| المصدر: |
BJOG: An International Journal of Obstetrics & Gynaecology; Nov2020, Vol. 127 Issue 12, p1548-1556, 9p |
| مصطلحات موضوعية: |
SARS-CoV-2, COVID-19, PUERPERAL disorders, CESAREAN section, COHORT analysis, COMMUNICABLE disease diagnosis, COMMUNICABLE disease epidemiology, CLINICAL pathology, VIRAL pneumonia, CASE-control method, PREGNANCY complications, HOSPITAL care, EPIDEMICS, LONGITUDINAL method, DISEASE complications |
| مصطلحات جغرافية: |
NEW York (N.Y.), NEW York (State) |
| مستخلص: |
Objective: To describe differences in outcomes between pregnant women with and without coronavirus dsease 2019 (COVID-19).Design: Prospective cohort study of pregnant women consecutively admitted for delivery, and universally tested via nasopharyngeal (NP) swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using reverse transcription-polymerase chain reaction. All infants of mothers with COVID-19 underwent SARS-CoV-2 testing.Setting: Three New York City hospitals.Population: Pregnant women >20 weeks of gestation admitted for delivery.Methods: Data were stratified by SARS-CoV-2 result and symptomatic status, and were summarised using parametric and nonparametric tests.Main Outcome Measures: Prevalence and outcomes of maternal COVID-19, obstetric outcomes, neonatal SARS-CoV-2, placental pathology.Results: Of 675 women admitted for delivery, 10.4% were positive for SARS-CoV-2, of whom 78.6% were asymptomatic. We observed differences in sociodemographics and comorbidities among women with symptomatic COVID-10 versus asymptomatic COVID-19 versus no COVID-19. Caesarean delivery rates were 46.7% in symptomatic COVID-19, 45.5% in asymptomatic COVID-19 and 30.9% in women without COVID-19 (P = 0.044). Postpartum complications (fever, hypoxia, readmission) occurred in 12.9% of women with COVID-19 versus 4.5% of women without COVID-19 (P < 0.001). No woman required mechanical ventilation, and no maternal deaths occurred. Among 71 infants tested, none were positive for SARS-CoV-2. Placental pathology demonstrated increased frequency of fetal vascular malperfusion, indicative of thrombi in fetal vessels, in women with COVID-19 versus women without COVID-19 (48.3% versus 11.3%, P < 0.001).Conclusion: Among pregnant women with COVID-19 at delivery, we observed increased caesarean delivery rates and increased frequency of maternal complications in the postpartum period. Additionally, intraplacental thrombi may have maternal and fetal implications for COVID-19 remote from delivery.Tweetable Abstract: COVID-19 at delivery: more caesarean deliveries, postpartum complications and intraplacental thrombi. [ABSTRACT FROM AUTHOR] |
|
Copyright of BJOG: An International Journal of Obstetrics & Gynaecology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder