التفاصيل البيبلوغرافية
العنوان: |
Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. |
المؤلفون: |
Lin, Albert L, Roman, Richard J, Regan, Kathleen A, Bolch, Charlotte A, Chen, Ching-Jygh, Iyer, Siva S.R. |
المصدر: |
International Journal of Molecular Sciences; Oct2020, Vol. 21 Issue 20, p7451-7451, 1p |
مصطلحات موضوعية: |
VITREOUS humor, DIABETIC retinopathy, PEOPLE with diabetes, RETINAL detachment, PATHOLOGY |
مستخلص: |
Proliferative diabetic retinopathy is a potentially blinding sequela of uncontrolled diabetes that involves a complex interaction of pro-angiogenic and inflammatory pathways. In this study, we compared the levels of pro-angiogenic arachidonic acid-derived mediators in human vitreous humor obtained from eyes with high-risk proliferative diabetic retinopathy versus controls. The results indicated that lipoxygenase and cytochrome P450-derived eicosanoids were elevated (5-HETE, 12-HETE, 20-HETE, and 20-COOH-AA), and there appeared to be no differences in levels measured in eyes with tractional retinal detachments versus those without. These results provide further insight into the pathogenesis of this disease and for the development of future potential therapeutic agents that target arachidonic acid metabolites to treat diabetic retinopathy. [ABSTRACT FROM AUTHOR] |
|
Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |