التفاصيل البيبلوغرافية
| العنوان: |
Blood utilization and clinical outcomes in pancreatic surgery before and after implementation of patient blood management. |
| المؤلفون: |
Frank, Steven M., Lo, Brian D., Yesantharao, Lekha V., Merkel, Kevin R., Qin, Caroline X., Cho, Brian C., Lee, K.H. Ken, Wintermeyer, Tyler L., Hebbar, Sachidanand, Burkhart, Richard A., Goel, Ruchika, Gehrie, Eric A. |
| المصدر: |
Transfusion; Nov2020, Vol. 60 Issue 11, p2581-2590, 10p |
| مصطلحات موضوعية: |
BLOOD, BLOOD platelet transfusion, PANCREATIC surgery, TIME measurements |
| مستخلص: |
Background: Over the past decade, patient blood management (PBM) programs have been developed to reduce allogeneic blood utilization. This is particularly important in pancreatic surgery, which has historically been associated with high transfusion requirements and morbid event rates. This study investigated blood utilization and clinical outcomes in pancreatic surgery before, during, and after the implementation of PBM. Study Design and Methods: A total of 3482 pancreatic surgery patients were assessed in a 10‐year retrospective cohort study (2009‐2019) at a single academic center. Baseline patient characteristics, transfusion practices, postoperative morbidity (infectious, thrombotic, ischemic, respiratory, and renal complications), mortality, and length of stay were compared between patients in the pre‐PBM (2009‐2013), early‐PBM (2014‐2016), and mature‐PBM (2017‐2019) time periods. Multivariable analysis assessed the odds for composite morbidity/mortality. Results: Comparing the mature‐PBM to pre‐PBM cohorts, transfused units per 100 discharged patients decreased by 53% for erythrocytes (155 to 73; P <.0001), 81% for plasma (79 to 15; P <.038), and 75% for platelets (10 to 2.5; P <.005). Clinical outcomes improved as well, with composite morbid event rates decreasing by more than 50%, from 236 in 1438 patients (16.4%) to 85 in 1145 patients (7.4%) (P <.0001). Mortality and length of stay remained unchanged. Compared to the pre‐PBM time period, early‐PBM was associated with a risk‐adjusted decrease in composite morbidity/mortality (OR 0.73; 95% CI 0.57‐0.93; P =.010), while mature‐PBM demonstrated a further incremental decrease (OR 0.44; 95% CI 0.33‐0.57; P <.0001). Conclusions: The implementation of PBM was associated with substantially decreased blood utilization in pancreatic surgery, without negatively impacting clinical outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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