التفاصيل البيبلوغرافية
| العنوان: |
Copper(I) and silver(I) complexes of anthraldehyde thiosemicarbazone: synthesis, structure elucidation, in vitro anti-tuberculosis/cytotoxic activity and interactions with DNA/HSA. |
| المؤلفون: |
Khan, Ashiq, Paul, Kamaldeep, Singh, Iqubal, Jasinski, Jerry P., Smolenski, Victoria A., Hotchkiss, Ethan P., Kelley, Patrick T., Shalit, Zachary A., Kaur, Manpreet, Banerjee, Somesh, Roy, Partha, Sharma, Rekha |
| المصدر: |
Dalton Transactions: An International Journal of Inorganic Chemistry; 12/21/2020, Vol. 49 Issue 47, p17350-17367, 18p |
| مصطلحات موضوعية: |
THIOSEMICARBAZONES, COPPER, SILVER, X-ray crystallography, DNA, COPPER compounds |
| مستخلص: |
A reaction of copper(I) halides (X = I, Br, Cl) and silver(I) halides with 9-anthraldehyde thiosemicarbazone (9-Hanttsc, H1L) and triphenylphosphine produced halogen-bridged dinuclear complexes, [M2(μ2-X)2(η1-S-9-Hanttsc)2(Ph3P)2] (M = Cu, X = Cl, 1; Br, 2; I, 3; M = Ag, X = Cl, 4; Br, 5). A similar reaction of 9-anthraldehyde-N1-methyl thiosemicarbazone (9-Hanttsc-N1-Me, H2L) with Ph3P and silver(I) halides yielded sulfur-bridged dimers, [Ag2X2(μ2-S-9-Hanttsc-N1-Me)2(Ph3P)2] (X = Cl, 9; Br, 10), however with copper(I) halides insoluble compounds were formed, which upon the addition of one extra mole of Ph3P gave mononuclear complexes of the formula [CuX(η1-S-9-Hanttsc-N1-Me)(Ph3P)2] (X = Cl, 6; Br, 7; I, 8). All of the complexes have been characterized by elemental analysis, NMR (1H, 13C) spectroscopy and single crystal X-ray crystallography (2, 5, 6, and 9). Both the ligands (H1L and H2L) and their complexes (1–10) were tested for their anti-tubercular and anticancer activities. The interactions of the ligands and their complexes (copper and silver) with calf thymus DNA (ct-DNA) and human serum albumin (HSA) were examined through UV-visible and fluorescence spectroscopy. Results showed that copper complex 2 displayed strong interactions with ct-DNA and HSA having binding constant values of 6.66 × 104 M−1 and 3.28 × 104 M−1, respectively, followed by silver complex 10 which gave binding constant values of 4.60 × 104 M−1 and 3.06 × 104 M−1, respectively. All of the complexes also showed good interactions with DNA in docking studies. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
