التفاصيل البيبلوغرافية
| العنوان: |
Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over 2‐year follow‐up. |
| المؤلفون: |
Moreton, F. C., Cullen, B., Dickie, D. A., Lopez Gonzalez, R., Santosh, C., Delles, C., Muir, K. W. |
| المصدر: |
European Journal of Neurology; Jan2021, Vol. 28 Issue 1, p220-228, 9p |
| مصطلحات موضوعية: |
CEREBRAL small vessel diseases, TRANSIENT ischemic attack, CAROTID intima-media thickness, BRAIN imaging, PROGNOSIS, CEREBRAL circulation |
| مستخلص: |
Background and purpose: Mutations in the NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a cerebral small vessel disease manifesting with stroke, migraine and dementia in adults. The disease displays significant phenotypic variability that is incompletely explained. Early abnormalities in vascular function have been shown in animal models. We postulated that studying changes in vascular function may offer insights into disease progression. Methods: Twenty‐two subjects with CADASIL [50% female, 50 (±11) years] from 19 pedigrees were included in a longitudinal multimodality study using brain magnetic resonance imaging (MRI), clinical measures, neuropsychology and measures of peripheral vascular function. MRI studies included measurement of structural brain changes, cerebral blood flow (CBF) and cerebrovascular reactivity by arterial spin labelling and a CO2 respiratory challenge. Results: Over 2 years, new stroke or transient ischaemic attack (TIA) occurred in five (23%) subjects and new significant disability in one (5%). There were significant increases in number of lacunes, subcortical hyperintensity volume and microbleeds, and a decrease in brain volume. CBF declined by 3.2 (±4.5) ml/100 g/min over 2 years. CBF and carotid–femoral pulse wave velocity at baseline predicted change in subcortical hyperintensity volume at follow‐up. Carotid intima‐media thickness and age predicted brain atrophy. Baseline CBF was lower in subjects who showed a decline in attention and working memory. Conclusions: Cerebral blood flow predicts radiological progression of hyperintensities and thus is a potential biomarker of disease progression in CADASIL. Over 2 years, there were changes in several relevant imaging biomarkers (CBF, brain volume, lacunes, microbleeds and hyperintensity volume). Future studies in CADASIL should consider assessment of CBF as prognostic factor. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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