التفاصيل البيبلوغرافية
| العنوان: |
Surgical Resection is Justifiable for Oral T4b Squamous Cell Cancers With Masticator Space Invasion. |
| المؤلفون: |
Baddour, H. Michael, Ochsner, Matthew C., Patel, Mihir R., Switchenko, Jeffrey M., Beitler, Jonathan J., Magliocca, Kelly, Baugnon, Kristen L., Solares, Clementino A., Steuer, Conor E., El‐Deiry, Mark W., El-Deiry, Mark W |
| المصدر: |
Laryngoscope; Feb2021, Vol. 131 Issue 2, pE466-E472, 7p |
| مستخلص: |
Objectives: To examine survival endpoints in patients with tumor (T)4b oral cavity squamous cell carcinoma (OCSCC) with pathologically proven masticator space invasion treated with primary surgery followed by adjuvant therapy.Study Design: Retrospective review at an academic cancer center.Methods: Twenty-five patients with T4b OCSCC with pathologic masticator space invasion were treated with primary surgery from May 2012 to December 2016. Only patients with ≥ 2 years follow-up from date of surgery were included. Sixteen patients received adjuvant chemoradiation.Results: Median follow-up time was 39 months from date of surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival at 24 months were 44.0%, 63.2%, and 52.6%, respectively. On univariate analyses, adjuvant chemoradiation was associated with improved OS. Advanced age and prolonged length of hospital stay was associated with worse OS.Conclusion: For pT4b OCSCCA involving the masticator space, primary surgical resection followed by adjuvant chemoradiation demonstrates 24-month DSS of > 50% and OS of 44%.Level Of Evidence: 4 Laryngoscope, 131:E466-E472, 2021. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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