التفاصيل البيبلوغرافية
| العنوان: |
Natural product of gambier (Uncaria gambier Roxb) extracts to counter against hepatotoxicity effects due to monosodium glutamate induction in male mice. |
| المؤلفون: |
Pane, Yunita, Machrina, Yetty, Hasan, Sufitni, Lumongga, Fitriani, Yunanda, Yuki |
| المصدر: |
Journal of Advanced Pharmaceutical Technology & Research; Jan-Mar2021, Vol. 12 Issue 1, p104-108, 5p |
| مصطلحات موضوعية: |
MONOSODIUM glutamate, HEPATOTOXICOLOGY, NATURAL products, ORGANS (Anatomy), MICROSCOPES |
| مستخلص: |
Monosodium glutamate (MSG) is often added in foods to enhance the flavor. It has adverse effect to body organs. Natural remedies, such as: gambier have been known for generations used to improve health. Substances contained in gambier, i.e.: catechins are believed to reduce the occurrence of hepatotoxicity. The study aims to analyze the effects of gambier in reducing the hepatotoxicity of MSG. This study with a posttest only control group design. Mice amount 25 (5 groups, n = 5/group). All interventions are given orally for 4 weeks. At the end of the study, it carried out euthanasia taken the liver of mice to made histopathology preparations then examine by light microscope, ×400, ×5 view field. Liver damage was found in each group with various levels of histological appearance:(I) 2 normal, 2 minimal, 1 moderate and none severe; (II) none normal, 1 minimal, 3 moderate and 1 severe; (III) 1 normal, 4 minimal, none moderate and severe;, (IV) 2 normal, 3 minimal, none moderate and severe; and (V) 4 normal, 1 minimal, none moderate, and severe. The data were analyzed using Kruskal–Wallis test. The level of liver damage among all groups was significantly different (p = 0.017). The same on the Dunn test also showed the level of liver damage in Group-II to compare with other groups (p < 0.05). The present study proves that Gambier (Uncaria gambier Roxb) can reduce occurrence of hepatotoxicity caused by MSG. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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