التفاصيل البيبلوغرافية
| العنوان: |
Perinatal outcome and prognostic factors of fetal megacystis diagnosed at 11–14 week's gestation. |
| المؤلفون: |
Kao, Cindy, Lauzon, Julie, Brundler, Marie‐Anne, Tang, Selphee, Somerset, David |
| المصدر: |
Prenatal Diagnosis; Feb2021, Vol. 41 Issue 3, p308-315, 8p |
| مستخلص: |
Objectives: To evaluate aneuploidy rate, prognostic factors, and perinatal outcomes following a diagnosis of fetal megacystis at 11–14 week's gestation. Methods: A retrospective study of first trimester fetal megacystis from 2010 to 2020 was performed, including ultrasound finding, perinatal outcomes, pathology reports, genetic tests, and neonatal investigations. Results A total of 98 cases of first trimester fetal megacystis was identified with an overall aneuploidy rate of 12%. There were 54% live births and 46% fetal losses including spontaneous fetal demise and elective termination. Among the 45 fetal losses, 64% had additional structural abnormalities at index ultrasound and final diagnoses were achievable in 64% cases. Among the 53 livebirths, additional ultrasound abnormalities were detected in only 1 fetus and spontaneous resolution of megacystis was detected in 96% of cases. The two cases where fetal megacystis persisted had major postnatal diagnoses: cloacal malformation and megacystis‐microcolon‐intestinal hypoperistalsis syndrome, respectively. Our data showed LBD ≥ 12 mm was the best individual predictor of adverse perinatal outcome and all 11 cases of lower urinary tract obstruction (LUTO) were diagnosed in fetuses with LBD ≥ 12 mm. Conclusions: First trimester ultrasound provides important prognostic factors and isolated megacystis <12 mm is associated with a positive outcome. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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