التفاصيل البيبلوغرافية
| العنوان: |
Synthesis and biological activity of pyridine acylhydrazone derivatives of isopimaric acid. |
| المؤلفون: |
Lu, Yan-Ju, Zhao, Zhen-Dong, Chen, Yu-Xiang, Wang, Jing, Xu, Shi-Chao, Gu, Yan |
| المصدر: |
Journal of Asian Natural Products Research; Jun2021, Vol. 23 Issue 6, p545-555, 11p |
| مصطلحات موضوعية: |
PYRIDINE, IN vitro studies, BIOCHEMISTRY, PHENOMENOLOGICAL biology, ANTI-infective agents, EARLY detection of cancer, HYDROCARBONS, PHENOMENOLOGY, CARBOXYLIC acids, RESEARCH funding, MOLECULAR structure, CELL lines, BIOLOGICAL assay, MICROBIAL sensitivity tests, BACTERIA |
| مستخلص: |
Pyridine acylhydrazone derivatives of isopimaric acid were synthesized and characterized. The minimum inhibitory concentrations of the compounds against five bacteria were determined and most of the compounds displayed some degree of antibacterial activity. The results showed that antimicrobial activity against Streptococcus pneumoniae improved when halogen atoms were introduced into the isopimaric acid, especially when one bromine atom was introduced in the para-position of isopimaric acid. Compound isopimaric acid (5-bromo pyridine-2-formaldehyde) acylhydrazone exhibited a significant antitumorial activity against hepatocarcioma cells (HepG-2) and breast cancer cells (MDA-MB-231), with inhibition degrees of 74.21% and 70.39%, respectively, at 100 μM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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