التفاصيل البيبلوغرافية
| العنوان: |
Protective Mechanism of Xiyin Liangxue Decoction on Immunoglobulin A Nephropathy Rats. |
| المؤلفون: |
JING WEI, MING LI, XIAOFANG YAN, CHUN LIU, ZEMEI ZHOU |
| المصدر: |
Indian Journal of Pharmaceutical Sciences; Mar/Apr2021, Vol. 83 Issue 2, p371-379, 9p |
| مصطلحات موضوعية: |
IGA glomerulonephritis, SPRAGUE Dawley rats, BLOOD urea nitrogen, ERYTHROCYTES, RATS, PLANT lectins, ASPARTATE aminotransferase |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Immunoglobulin A nephropathy is the most common glomerular disease in China, accounting for about 20 % to 47 % of primary glomerular diseases. Xiyin liangxue decoction is a common experience in the treatment of Immunoglobulin A nephropathy in recent years. The research of this formula in the clinical treatment of Immunoglobulin A nephropathy has achieved obvious curative effect. This article aims to study the protective mechanism of xiyin liangxue decoction on Immunoglobulin A nephropathy rats and analyzes and compares the advantages of xiyin liangxue decoction and western medicine in the treatment of Immunoglobulin A nephropathy rats with Sprague dawley nephropathy rats. The results of the study showed that after treatment of Immunoglobulin A nephropathy rats with xiyin liangxue decoction, the renal function of the rats in the treatment group was significantly improved, the expressions of alanine aminotransferase and aspartate aminotransferase increased by 19 % and 5 % and the expressions of albumin and globulin increased by 19 % and 25 %. In addition, in the treatment group, the number of urine red blood cells, urine protein and urine mannose binding lectin decreased by 29 %, 13 % and 25 %, respectively. The urine volume of rats in the high dose group was significantly reduced by 13 % and the expressions of blood urea nitrogen and blood creatinine increased 22 % and 8 % respectively. After treatment with xiyin liangxue decoction, the cure rate of experimental Immunoglobulin A rats reached 24 % and 33 % had significant improvement. It can be seen that xiyin liangxue decoction has a good clinical treatment effect on Immunoglobulin A nephropathy rats. [ABSTRACT FROM AUTHOR] |
|
Copyright of Indian Journal of Pharmaceutical Sciences is the property of Indian Journal of Pharmaceutical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
