التفاصيل البيبلوغرافية
| العنوان: |
Characterization of blood vessels in bone marrow from patients with chronic myeloid leukemia and polycythemia vera. |
| المؤلفون: |
Zetterberg, E., Lundberg, L. G., Palmblad, J. |
| المصدر: |
Scandinavian Journal of Clinical & Laboratory Investigation; Nov2004, Vol. 64 Issue 7, p641-647, 7p |
| مصطلحات موضوعية: |
BLOOD vessels, NEOVASCULARIZATION, BONE marrow, MYELOID leukemia, ERYTHROCYTE disorders, IMMUNE system |
| مستخلص: |
Angiogenesis is a feature of hematological malignancies which may provide prognostic information. However, there is, as yet, no established marker for leukemia-associated vessels in bone marrow. In this study, immunohistochemical stainings for von Willebrand factor (vWf), CD34, Tie-2, angiomodulin, glycodelin, cycloxygenase-2 (Cox-2) and endoglin were compared in order to identify the bone marrow vasculature. Chronic myeloid leukemia (CML), a disease displaying intense angiogenesis, and polycythemia vera (PV), a disease with a low microvascular density (MVD), were studied, as well as normal bone marrow. Only vWf, CD34 and Tie-2 stained the bone marrow endothelium. Although more vessels were stained for vWf than for CD34, there was no evidence that vWf stained more disease-associated vessels. In double staining, Tie-2 co-localized with CD34, but vessels staining only for Tie-2 were also found. However, the number of Tie-2-positive vessels did not correlate to either the MVD or the disease. Angiomodulin, glycodelin, Cox-2 and endoglin did not stain vessel-like structures. In conclusion, estimating the MVD by means of CD34 staining appears to be the most reliable method, but none of the tested molecules qualified as a specific marker for leukemia-associated vessels in the bone marrow. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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