التفاصيل البيبلوغرافية
| العنوان: |
p-Terphenyls and actinomycins from a Streptomyces sp. associated with the larva of mud dauber wasp. |
| المؤلفون: |
Lu, Dan-Dan, Ren, Jin-Wei, Du, Qian-Qian, Song, Ya-Jie, Lin, Shi-Qi, Li, Xia, Li, Er-Wei, Xie, Wei-Dong |
| المصدر: |
Natural Product Research; Jun2021, Vol. 35 Issue 11, p1869-1873, 5p |
| مصطلحات موضوعية: |
ACTINOMYCIN, BREAST cancer, DACTINOMYCIN, STREPTOMYCES, LARVAE |
| مستخلص: |
In the course of searching for cytotoxic metabolites from insects associated actinomyces, two new natural p-terphenyl glycosides, strepantibin D (1) and strepantibin E (2), along with terferol (3), actinomycin D (4), actinomycin V (5) and actinomycin V0β (6), were identified from the fermentation medium of a Streptomyces sp. which was obtained from the larva body of mud dauber wasp. Strepantibin D (1), previously reported as a synthetic derivative of terfestatin A, is firstly isolated as a natural p-terphenyl in this research. Strepantibin D (1) and terferol (3) showed medium cytotoxic activity against breast cancer cells MCF-7, MDA-MB-231 and BT-474. Actinomycins (4-6), especially actinomycin V (5), displayed remarkable cytotoxicity against breast cancer cells, with IC50 values ranging from 0.83 nM to 369.90 nM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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