التفاصيل البيبلوغرافية
| العنوان: |
Germline sexual fate is determined by the antagonistic action of dmrt1 and foxl3/foxl2 in tilapia. |
| المؤلفون: |
Shengfei Dai, Shuangshuang Qi, Xueyan Wei, Xingyong Liu, Yibing Li, Xin Zhou, Hesheng Xiao, Baoyue Lu, Deshou Wang, Minghui Li |
| المصدر: |
Development (09501991); Apr2021, Vol. 148 Issue 8, p1-14, 14p |
| مصطلحات موضوعية: |
SOMATIC cells, TILAPIA, GENETIC mutation, GERM cells, AROMATASE inhibitors, SOMATIC mutation |
| مستخلص: |
Germline sexual fate has long been believed to be determined by the somatic environment, but this idea is challenged by recent studies of foxl3mutants inmedaka. Here, we demonstrate that the sexual fate of tilapia germline is determined by the antagonistic interaction of dmrt1 and foxl3, which are transcriptionally repressed in male and female germ cells, respectively. Loss of dmrt1 rescued the germ cell sex reversal in foxl3Δ7/Δ7 XX fish, and loss of foxl3 partially rescued germ cell sex reversal but not somatic cell fate in dmrt1Δ5/Δ5 XY fish. Interestingly, germ cells lost sexual plasticity in dmrt1Δ5/Δ5 XY and foxl3Δ7/Δ7 XX singlemutants, as aromatase inhibitor (AI) and estrogen treatment failed to rescue the respective phenotypes. However, recovery of germ cell sexual plasticity was observed in dmrt1/foxl3 double mutants. Importantly, mutation of somatic cell-specific foxl2 resulted in testicular development in foxl3Δ7/Δ7 or dmrt1Δ5/Δ5 mutants. Our findings demonstrate that sexual plasticity of germ cells relies on the presence of both dmrt1 and foxl3. The existence of dmrt1 and foxl3 allows environmental factors to influence the sex fate decision in vertebrates. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
