التفاصيل البيبلوغرافية
| العنوان: |
Partial and nonresponders to onabotulinumtoxinA can benefit from anti‐CGRP monoclonal antibodies preventive treatment: A real‐world evidence study. |
| المؤلفون: |
Alpuente, Alicia, Gallardo, Victor J., Caronna, Edoardo, Torres‐Ferrús, Marta, Pozo‐Rosich, Patricia |
| المصدر: |
European Journal of Neurology; Jul2021, Vol. 28 Issue 7, p2378-2382, 5p |
| مصطلحات موضوعية: |
BOTULINUM A toxins, MONOCLONAL antibodies, EVIDENCE |
| مستخلص: |
Background and purpose: Monoclonal antibodies targeting CGRP or its receptor, anti‐CGRP mAbs, are proven to be effective treatments in migraine prevention. Real‐world evidence studies assessing their efficacy are scarce. Methods: Our objective was to assess the efficacy of anti‐CGRP mAbs in our clinical cohort resistant to onabotulinumtoxinA. We prospectively analyzed ≥50% response rate in patients who initiated treatment with anti‐CGRP mAbs and who were partial or nonresponders to onabotulinumtoxinA. Results: One hundred fifty‐five patients completed treatment with anti‐CGRP mAbs at 3 months of follow‐up. No statistically significant differences were found in ≥50% response in headache frequency in patients with prior onabotulinumtoxinA treatment partial or complete failure. Regarding dual therapy with onabotulinumtoxinA and anti‐CGRP mAbs, no statistically significant differences were found in ≥50% response in headache frequency between monotherapy or dual therapy. Conclusions: Patients with prior treatment failure or partial efficacy to onabotulinumtoxinA respond to anti‐CGRP mAbs. After 3 months, in our cohort, dual therapy does not seem to add more benefit than anti‐CGRP mAbs in monotherapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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