التفاصيل البيبلوغرافية
| العنوان: |
Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. |
| المؤلفون: |
Brügger, Melanie, Démoulins, Thomas, Barut, G. Tuba, Zumkehr, Beatrice, Oliveira Esteves, Blandina I., Mehinagic, Kemal, Haas, Quentin, Schögler, Aline, Rameix-Welti, Marie-Anne, Eléouët, Jean-François, Moehrlen, Ueli, Marti, Thomas M., Schmid, Ralph A., Summerfield, Artur, Posthaus, Horst, Ruggli, Nicolas, Hall, Sean R. R., Alves, Marco P. |
| المصدر: |
PLoS Pathogens; 7/28/2021, Vol. 17 Issue 7, p1-28, 28p |
| مصطلحات موضوعية: |
RESPIRATORY syncytial virus infections, MESENCHYMAL stem cells, LUNG infections, T cells, RESPIRATORY syncytial virus, CELL physiology, TISSUE remodeling |
| مستخلص: |
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent respiratory syncytial virus (RSV) which causes severe outcomes in infants. We applied complementary approaches with primary pediatric LR-MSCs and a state-of-the-art model of human RSV infection in lamb. Remarkably, RSV-infection of pediatric LR-MSCs led to a robust activation, characterized by a strong antiviral and pro-inflammatory phenotype combined with mediators related to T cell function. In line with this, following in vivo infection, RSV invades and activates LR-MSCs, resulting in the expansion of the pulmonary MSC pool. Moreover, the global transcriptional response of LR-MSCs appears to follow RSV disease, switching from an early antiviral signature to repair mechanisms including differentiation, tissue remodeling, and angiogenesis. These findings demonstrate the involvement of LR-MSCs during virus-mediated acute lung injury and may have therapeutic implications. Author summary: This work identifies a novel function of lung-resident MSCs during virus-induced acute lung injury. These findings contribute to the understanding of host response and lung repair mechanisms during a highly prevalent clinical situation and may have therapeutic implications. [ABSTRACT FROM AUTHOR] |
|
Copyright of PLoS Pathogens is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder