التفاصيل البيبلوغرافية
العنوان: |
Volatile anaesthesia and peri-operative outcomes related to cancer: a feasibility and pilot study for a large randomised control trial. |
المؤلفون: |
Dubowitz, J. A., Cata, J. P., De Silva, A. P., Braat, S., Shan, D., Yee, K., Hollande, F., Martin, O., Sloan, E. K., Riedel, B., Hiller, J., Koldej, R., Leslie, K., Myles, P., Buggy, D., Wigmore, T., Gottumukkala, V., Sessler, D. I., Global Onco-Anaesthesia Research Collaboration Group |
المصدر: |
Anaesthesia; Sep2021, Vol. 76 Issue 9, p1198-1206, 9p |
مصطلحات موضوعية: |
ONCOLOGIC surgery, INTRAVENOUS anesthesia, CANCER prognosis, ANESTHESIA, PILOT projects, FEASIBILITY studies, RANDOMIZED controlled trials, TUMOR surgery, PROPOFOL, INHALATION anesthetics, RESEARCH, INHALATION anesthesia, RESEARCH methodology, SURGICAL complications, MEDICAL cooperation, EVALUATION research, INTRAVENOUS anesthetics, COMPARATIVE studies, BLIND experiment, RESEARCH funding |
مصطلحات جغرافية: |
AUSTRALIA, UNITED States |
مستخلص: |
Published data suggest that the type of general anaesthesia used during surgical resection for cancer may impact on patient long-term outcome. However, robust prospective clinical evidence is essential to guide a change in clinical practice. We explored the feasibility of conducting a randomised controlled trial to investigate the impact of total intravenous anaesthesia with propofol vs. inhalational volatile anaesthesia on postoperative outcomes of patients undergoing major cancer surgery. We undertook a randomised, double-blind feasibility and pilot study of propofol total intravenous anaesthesia or volatile-based maintenance anaesthesia during cancer resection surgery at three tertiary hospitals in Australia and the USA. Patients were randomly allocated to receive propofol total intravenous anaesthesia or volatile-based maintenance anaesthesia. Primary outcomes for this study were successful recruitment to the study and successful delivery of the assigned anaesthetic treatment as per randomisation arm. Of the 217 eligible patients approached, 146 were recruited, a recruitment rate of 67.3% (95%CI 60.6-73.5%). One hundred and forty-five patients adhered to the randomised treatment arm, 99.3% (95%CI 96.2-100%). Intra-operative patient characteristics and postoperative complications were comparable between the two intervention groups. This feasibility and pilot study supports the viability of the protocol for a large, randomised controlled trial to investigate the effect of anaesthesia technique on postoperative cancer outcomes. The volatile anaesthesia and peri-operative outcomes related to cancer (VAPOR-C) study that is planned to follow this feasibility study is an international, multicentre trial with the aim of providing evidence-based guidelines for the anaesthetic management of patients undergoing major cancer surgery. [ABSTRACT FROM AUTHOR] |
|
Copyright of Anaesthesia is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
قاعدة البيانات: |
Complementary Index |