التفاصيل البيبلوغرافية
| العنوان: |
A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats. |
| المؤلفون: |
Rubin, Elina, Pippione, Agnese C., Boyko, Matthew, Einaudi, Giacomo, Sainas, Stefano, Collino, Massimo, Cifani, Carlo, Lolli, Marco L., Abu-Freha, Naim, Kaplanski, Jacob, Boschi, Donatella, Azab, Abed N. |
| المصدر: |
Brain Sciences (2076-3425); Jan2022, Vol. 12 Issue 1, p35-35, 1p |
| مصطلحات موضوعية: |
NF-kappa B, ENCEPHALITIS, ISCHEMIC stroke, RATS |
| مستخلص: |
Aim: Nuclear factor kappa B (NF-κB) is known to play an important role in the inflammatory process which takes place after ischemic stroke. The major objective of the present study was to examine the effects of MEDS-23, a potent inhibitor of NF-κB, on clinical outcomes and brain inflammatory markers in post-ischemic stroke rats. Main methods: Initially, a Toxicity Experiment was performed to determine the appropriate dose of MEDS-23 for use in animals, as MEDS-23 was analyzed in vivo for the first time. We used the middle cerebral artery occlusion (MCAO) model for inducing ischemic stroke in rats. The effects of MEDS-23 (at 10 mg/kg, ip) on post-stroke outcomes (brain inflammation, fever, neurological deficits, mortality, and depression- and anxiety-like behaviours) was tested in several efficacy experiments. Key findings: MEDS-23 was found to be safe and significantly reduced the severity of some adverse post-stroke outcomes such as fever and neurological deficits. Moreover, MEDS-23 significantly decreased prostaglandin E2 levels in the hypothalamus and hippocampus of post-stroke rats, but did not prominently alter the levels of interleukin-6 and tumor necrosis factor-α. Significance: These results suggest that NF-κB inhibition is a potential therapeutic strategy for the treatment of ischemic stroke. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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