التفاصيل البيبلوغرافية
| العنوان: |
Micro-sized composite drugs based on sodium caseinate for inhalation administration. |
| المؤلفون: |
Boldyrev, Artur E., Ziganshin, Marat A., Lyadov, Nikolay M., Klimovitskii, Alexander E., Zubaidullina, Liana S., Gerasimov, Alexander V. |
| المصدر: |
AIP Conference Proceedings; 2022, Vol. 2390 Issue 1, p1-5, 5p |
| مصطلحات موضوعية: |
INHALATION administration, MILK proteins, EXTRACELLULAR matrix proteins, SPRAY drying, DRUG administration, CASEINS, SODIUM caseinate |
| مستخلص: |
The development of alternative methods of drug administration is an actual area of modern pharmaceuticals. Inhalation administration is one of the promising routes. Casein is the optimal matrix for creating dosage forms with improved characteristics due to the developed surface with many binding sites, biocompatibility, and the possibility of forming nano aggregates in a solution. The high thermal stability of milk proteins as well as the ability to control their solubility makes it possible to use the spray drying method to obtain composite microparticles with a narrow size distribution. Such microparticles can be used in the inhalation delivery of drugs of both local and systemic effects. In the present work, microparticles of a model drug with sodium caseinate were obtained. The average diameter of the obtained particles was 1.2 µm. It was shown that the protein matrix provides an increase in the drug content in solution with a high release rate, which is necessary for inhalation delivery. The results can be used to create drug administration systems based on protein molecules of various nature. [ABSTRACT FROM AUTHOR] |
|
Copyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Find this article in full text from Scitation.