التفاصيل البيبلوغرافية
| العنوان: |
Safety and Efficacy of Single-Dose Ketorolac for Postoperative Pain Management After Primary Palatoplasty: A Prospective Cohort Study With Historical Controls. |
| المؤلفون: |
Stein, Jason R., Mantilla-Rivas, Esperanza, Aivaz, Marudeen, Rana, Md Sohel, Mamidi, Ishwarya Shradha, Ichiuji, Brynne A., Manrique, Monica, Rogers, Gary F., Finkel, Julia C., Oh, Albert K. |
| المصدر: |
Cleft Palate Craniofacial Journal; Apr2022, Vol. 59 Issue 4, p505-512, 8p |
| مصطلحات موضوعية: |
DRUG efficacy, LENGTH of stay in hospitals, STATISTICAL power analysis, CONFIDENCE intervals, EFFECT sizes (Statistics), CLEFT palate, HEALTH outcome assessment, FISHER exact test, CLEFT lip, MATHEMATICAL variables, T-test (Statistics), CHI-squared test, DESCRIPTIVE statistics, DATA analysis software, POSTOPERATIVE pain, KETOROLAC, PAIN management, LONGITUDINAL method, EVALUATION |
| مستخلص: |
Objective: To analyze safety and efficacy of single-dose ketorolac after primary palatoplasty (PP). Design: Consecutive cohort of patients undergoing PP, comparing to historical controls. Setting: A large academic children's hospital. Patients, Participants: A consecutive cohort of 111 patients undergoing PP (study n = 47) compared to historical controls (n = 64). Interventions: All patients received intraoperative acetaminophen, dexmedetomidine, and opioids while the study group received an additional single dose of ketorolac (0.5 mg/kg) at the conclusion of PP. Main Outcome Measures: Safety of ketorolac was measured by significant bleeding complications and need for supplementary oxygen. Efficacy was assessed through bleeding, Face Legs Activity Cry Consolability (FLACC) scale, and opioid dose. Results: Length of stay was similar for both groups (control group 38.5 hours [95% CI: 3.6-43.3] versus study group 37.6 hours [95% CI: 31.3-44.0], P =.84). There were no significant differences in all postoperative FLACC scales. The mean dose of opioid rescue medication measured as morphine milligram equivalents did not differ between groups (P =.56). Significant postoperative hemorrhage was not observed. Conclusions: This is the first prospective study to evaluate the safety and efficacy of single-dose ketorolac after PP. Although lack of standardization between study and historical control groups may have precluded observation of an analgesic benefit, analysis demonstrated a single dose of ketorolac after PP is safe. Further investigations with more patients and different postoperative regimens may clarify the role of ketorolac in improving pain after PP. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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