دورية أكاديمية
องค์ประกอบทางเคมี ความเป็นพิษต่อเซลล์ ฤทธิ์ยับยั้งการผลิตไนตริกออกไซด์ การทำ�งาน ของเอนไซม์แอลฟากลูโคซิเดส และฤทธิ์ต้านอนุมูลอิสระของสารสกัดเอทานอลใบหนาน เฉาเหว่ย (Vernonia amygdalina Delile)
| العنوان: | องค์ประกอบทางเคมี ความเป็นพิษต่อเซลล์ ฤทธิ์ยับยั้งการผลิตไนตริกออกไซด์ การทำ�งาน ของเอนไซม์แอลฟากลูโคซิเดส และฤทธิ์ต้านอนุมูลอิสระของสารสกัดเอทานอลใบหนาน เฉาเหว่ย (Vernonia amygdalina Delile) (Thai) |
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| Alternate Title: | Chemical constituents, cytotoxicity, inhibitory effect on nitric oxide production, α-glucosidase activity, and antioxidant activity of ethanol leaf extract from Gymnanthemum extensum (Vernonia amygdalina Delile). (English) |
| المؤلفون: | วรินทร อินทน้ำ�เงิน, นพรัตน์ พุทธกาล |
| المصدر: | Journal of Science & Technology MSU; Jan/Feb2022, Vol. 41 Issue 1, p1-17, 17p |
| مصطلحات موضوعية: | BIOACTIVE compounds, PALMITIC acid, BENZOIC acid, STEARIC acid, ETHER (Anesthetic), ETHANOL, ETHYL esters |
| مستخلص: | Investigation on the chemical constituents, cytotoxicity, inhibitory effect on nitric oxide (NO) production and α-glucosidase activity, and anti-oxidant activity of the ethanol leaf extract from Vernonia amygdalina Del. (LEVA) revealed that using Gas Chromatograph-Mass Spectrometer (GC-MS), ten chemical compounds, benzoic acid, neophytadiene, xylocaine, hexadecanoic acid, hexadecanoic acid ethyl ether, phytol, (z,z) -9,12-octadecadienoic acid, (z,z,z) -9,12,15-octadecatrien-1-ol, (z,z,z) -9,12,15-octadecatrienoic acid ethyl ester, and octadecanoic acid were present in LEVA. Some chemicals found in LEVA are being active compounds responded to the activities of LEVA. In addition, LEVA was cytotoxic to LPS-stimulated RAW 246.7 macrophages with IC50 value of 110.02±0.86 μg/ml. Moreover, LEVA exhibited inhibition of nitric oxide (NO) production and α-glucosidase activity, and possessed DPPH scavenging property. LEVA exerted anti-inflammatory activity via an inhibition on NO production, an antidiabetic effect via an inhibition on α-glucosidase activity, and antioxidant activity via DPPH scavenging. It is likely that the bioactive compounds present in LEVA are responses to these activities. In additions the present study supported the traditional use of V. amygdalina for the diabetic treatment. However, application of high amount of this plant should be considered. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: | Complementary Index |
Full Text Finder | تدمد: | 16869664 |
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