التفاصيل البيبلوغرافية
| العنوان: |
Topical κ‐opioid receptor agonist asimadoline improves dermatitis in a canine model of atopic dermatitis. |
| المؤلفون: |
Marsella, Rosanna, Ahrens, Kim, Wilkes, Rachel, Soeberdt, Michael, Abels, Christoph |
| المصدر: |
Experimental Dermatology; Apr2022, Vol. 31 Issue 4, p628-632, 5p |
| مصطلحات موضوعية: |
ATOPIC dermatitis, HOUSE dust mites, SKIN inflammation, VISUAL analog scale, ITCHING |
| مستخلص: |
This prospective, 4‐week, placebo‐controlled, cross‐over study aimed to investigate the efficacy of 1% topical κ‐opioid agonist, asimadoline, in a model of canine atopic dermatitis (AD). Fourteen beagles were challenged with house dust mites every 3–4 days for a total of 9 challenges. Severity of dermatitis was assessed, and pruritus was monitored using GoPro HERO cameras. Pruritus scoring was evaluated at 10 time periods; baseline, 4 h post allergen challenge and the last day of the study on Day 28. Scoring was done blindly by personnel using BORIS software. A global subjective score was also given using a visual analogue scale (VAS). A 4‐week washout period occurred and dogs were crossed‐over, the study was repeated, and the results were analysed using combined data. Gel was applied once daily on inguinal area (0.6 ml/dog). ANOVA showed significant effect of time (p < 0.0001) and group (p = 0.0001) on dermatitis scores. Overall, no statistically significant effect on pruritus was found due to a crossing of scores on Day 17. Overtime the placebo scores increased while the active ingredient showed decrease after first 3 weeks. It is concluded that this approach is promising in dogs with AD and longer studies with more frequent application may be beneficial. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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